Immunology is one of the most rapidly developing fields of medical science. Increasing understanding of the regulation of immune responses has led to the launch of several new therapeutic agents for clinical use, especially in cancer. However, not all cancer patients are responding to current immunological treatments and no cure or prevention is available for autoimmune diseases.
The ambitious goal of TRIMM is to explore the development and regulation of T cells and immune tolerance and understand the aberrant immune responses in auto- and alloimmune diseases and cancer. Our ultimate goal is to translate the discoveries into prevention, novel disease classifications, diagnostic tools, and personalized treatment.
O1: Explore the development and regulation of T cells and immune tolerance
O2: Understand the aberrant immune responses in auto- and alloimmune diseases and cancer
O3: Translate the discoveries into prevention, novel disease classifications, diagnostic tools, and personalized treatment
Satu Mustjoki
Hematology Research Unit
Biomedicum Helsinki 1
Haartmaninkatu 8
P.O. Box 63
FI-00014 University of Helsinki
Tel: +358 9 471 71898
satu.mustjoki@helsinki.fi
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Johansson, T., Partanen, J. & Saavalainen, P. HLA allele-specific expression: Methods, disease associations, and relevance in hematopoietic stem cell transplantation. Front Immunol 13, 1007425 (2022).
Mustjoki, S. & Young, N.S. Somatic Mutations in "Benign" Disease. N Engl J Med 384, 2039-2052 (2021).
Valori, M., Jansson, L. & Tienari, P.J. CD8+ cell somatic mutations in multiple sclerosis patients and controls-Enrichment of mutations in STAT3 and other genes implicated in hematological malignancies. PLoS One 16, e0261002 (2021).
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Kudling, T.V., Clubb, J.H.A., Quixabeira, D.C.A., Santos, J.M., Havunen, R., Kononov, A., Heiniö, C., Cervera-Carrascon, V., Pakola, S., Basnet, S., Grönberg-Vähä-Koskela, S., Arias, V., Gladwyn-Ng, I., Aro, K., Bäck, L., Räsänen, J., Ilonen, I., Borenius, K., Räsänen, M., Hemminki, O., Rannikko, A., Kanerva, A., Tapper, J. & Hemminki, A. Local delivery of interleukin 7 with an oncolytic adenovirus activates tumor-infiltrating lymphocytes and causes tumor regression. Oncoimmunology 11, 2096572 (2022).
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Feola, S., Haapala, M., Peltonen, K., Capasso, C., Martins, B., Antignani, G., Federico, A., Pietiäinen, V., Chiaro, J., Feodoroff, M., Russo, S., Rannikko, A., Fusciello, M., Koskela, S., Partanen, J., Hamdan, F., Tähkä, S.M., Ylösmäki, E., Greco, D., Grönholm, M., Kekarainen, T., Eshaghi, M., Gurvich, O.L., Ylä-Herttuala, S., RM, M.B., Lehtiö, J., Sikanen, T.M. & Cerullo, V. PeptiCHIP: A Microfluidic Platform for Tumor Antigen Landscape Identification. ACS Nano 15, 15992-16010 (2021).
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